Description

6-Azaspiro[2.5]Octan-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its constrained spirocyclic structure.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Academic & Contract Research: Employed in academic laboratories and CROs (Contract Research Organizations) for exploratory synthesis and biological screening.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or warhead design for targeted protein degradation therapeutics.

Basic Information

Product Name	6-Azaspiro[2.5]Octan-4-One Hydrochloride
CAS No.	1408076-12-9
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	6-Azaspiro[2.5]octan-4-one, hydrochloride; 4-Oxo-6-azaspiro[2.5]octane hydrochloride; 1-Azaspiro[2.5]octan-7-one hydrochloride (possible numbering variation); 6-Oxa-1-azaspiro[2.5]octan-4-one hydrochloride; Spiro[cyclopropane-1,2'-piperidin]-4'-one hydrochloride; Azaspirooctanone HCl; CAS 1408076-12-9
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[2.5]Octan-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.