Description

tert-Butyl 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic and heterocyclic architecture. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those containing complex spirocyclic frameworks.
• Protease Inhibitor Research: Serves as a core scaffold or precursor in the development of inhibitors for various protease enzymes.
• CNS Drug Discovery: Used in constructing pharmacophores for potential neurological and psychiatric disorder treatments.
• Antiviral Agent Development: Employed in research programs targeting new antiviral compounds due to its structural motifs.
• Chemical Biology & Probe Synthesis: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for optimizing robust and scalable API manufacturing routes under GMP guidelines.

Basic Information

Product Name	tert-Butyl 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1408075-90-0
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	2-[(tert-Butoxy)carbonyl]-7-oxo-5-oxa-2-azaspiro[3.4]octane; 5-Oxa-2-azaspiro[3.4]octane-2-carboxylic acid, 7-oxo-, 1,1-dimethylethyl ester; tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 7-Oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; Boc-Protected 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane; Spirocyclic Oxazolidinone Ester Intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Oxo-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.