Description

Ethyl 2-(trans-3-Hydroxycyclobutyl)Acetate is a high-value, functionalized cyclobutane derivative that serves as a versatile chiral building block in advanced organic synthesis. Its unique structure, featuring a trans-configured hydroxycyclobutyl moiety, makes it a critical intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders, antiviral agents, and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclobutane ring can contribute to unique biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fragrance and Flavor Chemistry: The ester functionality and constrained ring system can be utilized to create novel aroma chemicals with unique olfactory properties.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with tailored thermal and mechanical properties.
• Academic and Contract Research: Employed in university and CRO laboratories for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	Ethyl 2-(trans-3-Hydroxycyclobutyl)Acetate
CAS No.	1408075-85-3
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	trans-Ethyl 3-Hydroxycyclobutaneacetate; Ethyl (trans-3-Hydroxycyclobutyl)acetate; 2-(trans-3-Hydroxycyclobutyl)acetic Acid Ethyl Ester; Acetic Acid, 2-(trans-3-Hydroxycyclobutyl)-, Ethyl Ester; (trans-3-Hydroxycyclobutyl)acetic Acid Ethyl Ester; Ethyl trans-3-Hydroxycyclobutylacetate; 1408075-85-3; Ethyl (1r,3r)-3-Hydroxycyclobutaneacetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(trans-3-Hydroxycyclobutyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.