Description

trans-Methyl 3-Hydroxy-1-Methylcyclobutanecarboxylate is a high-purity, functionalized cyclobutane derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique stereochemistry and bifunctional nature make it a valuable intermediate for constructing complex molecular architectures with precise spatial orientation. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where the specific spatial configuration is crucial for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemical purity.
• Academic and Industrial Research: A valuable tool for methodological studies in organic chemistry, particularly in ring-opening and functionalization reactions of strained carbocycles.
• Material Science Precursor: Potential use in synthesizing monomers for specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	trans-Methyl 3-Hydroxy-1-Methylcyclobutanecarboxylate
CAS No.	1408075-48-8
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	Methyl (1R,3S)-3-hydroxy-1-methylcyclobutanecarboxylate; (1R,3S)-3-Hydroxy-1-methylcyclobutanecarboxylic acid methyl ester; trans-3-Hydroxy-1-methylcyclobutanecarboxylic acid methyl ester; (1R,3S)-1-Methyl-3-hydroxycyclobutanecarboxylic acid methyl ester; Methyl trans-3-hydroxy-1-methylcyclobutanecarboxylate; Cyclobutanecarboxylic acid, 3-hydroxy-1-methyl-, methyl ester, trans-; 1408075-48-8; trans-1-Methyl-3-hydroxycyclobutanecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our trans-Methyl 3-Hydroxy-1-Methylcyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and stereochemical purity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (HPLC/GC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.