Description

trans-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanol is a high-value, protected cyclobutanol derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound serves as a crucial chiral building block and synthetic intermediate in advanced organic synthesis, enabling the controlled introduction of the cyclobutanol moiety under mild conditions. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Advanced Organic Synthesis: Used as a protected alcohol precursor in multi-step syntheses, including cross-coupling reactions, nucleophilic additions, and ring-opening transformations.
• Agrochemical Research: Intermediate in the development of novel herbicides and fungicides with specific stereochemical requirements.
• Material Science: Building block for synthesizing specialized monomers or ligands used in catalyst design and polymer chemistry.
• Process Chemistry: Employed in route scouting and scale-up for the efficient production of target molecules requiring the cyclobutanol scaffold.

Basic Information

Product Name	trans-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanol
CAS No.	1408075-44-4
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	trans-3-((tert-Butyldimethylsilyl)oxy)cyclobutanol; (1r,3r)-3-[(tert-Butyldimethylsilyl)oxy]cyclobutanol; trans-3-(TBDMS-oxy)cyclobutanol; trans-3-O-TBDMS-cyclobutanol; (trans)-3-(tert-Butyldimethylsiloxy)cyclobutanol; Cyclobutanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, trans-; TBDMS ether of trans-3-hydroxycyclobutane
EINECS	Contact for details

Quality Control

Our trans-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and MS, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.