Description

Ethyl (3-Hydroxycyclobutyl)Acetate is a specialized organic ester compound featuring a cyclobutanol moiety, serving as a valuable chiral building block and intermediate in advanced organic synthesis. Its unique structure, combining a strained four-membered ring with both ester and alcohol functionalities, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in projects targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the cyclobutane ring can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry.
• Fragrance and Flavor Chemistry: Potential use as an intermediate for synthesizing unique aroma chemicals with complex, woody, or green notes due to its ester-alcohol structure.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing specialty polymers with tailored thermal and mechanical properties.
• Academic and Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies in ring-opening and functionalization chemistry.

Basic Information

Product Name	Ethyl (3-Hydroxycyclobutyl)Acetate
CAS No.	1408075-22-8
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	Ethyl 3-hydroxycyclobutaneacetate; 3-Hydroxycyclobutylacetic Acid Ethyl Ester; Acetic acid, 2-(3-hydroxycyclobutyl)-, ethyl ester; Ethyl (3-hydroxycyclobutyl)ethanoate; (3-Hydroxycyclobutyl)acetic acid ethyl ester; Ethyl 2-(3-hydroxycyclobutyl)acetate; Cyclobutanol, 1-acetic acid, ethyl ester (related); 1408075-22-8
EINECS	Contact for details

Quality Control

Our Ethyl (3-Hydroxycyclobutyl)Acetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) that include results from GC, HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is compatible with strong alkali/organic solvents; however, it should be kept away from strong oxidizing agents and stored under an inert atmosphere if long-term stability is a concern. Keep the container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.