Description

Ethyl (1S,3R)-3-Hydroxy-1-Methylcyclobutane-1-Carboxylate is a high-purity chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex, stereochemically defined molecules, particularly in the pharmaceutical sector. It is primarily needed by research and development teams in pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and complex natural products.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with specific stereochemical activity.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new asymmetric catalytic processes.
• Fine Chemical Manufacturing: Employed in the custom synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Contract Research: A valuable tool for synthetic chemistry research in academic institutions and Contract Research Organizations (CROs).
• Material Science Precursor: Potential use in the synthesis of specialized polymers or functional materials requiring specific molecular geometry.

Basic Information

Product Name	Ethyl (1S,3R)-3-Hydroxy-1-Methylcyclobutane-1-Carboxylate
CAS No.	1408074-72-5
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	(1S,3R)-3-Hydroxy-1-methylcyclobutane-1-carboxylic acid ethyl ester; Ethyl (1S,3R)-3-hydroxy-1-methylcyclobutane-1-carboxylate; (1S,3R)-Ethyl 3-hydroxy-1-methylcyclobutane-1-carboxylate; (1S,3R)-1-Methyl-3-hydroxycyclobutane-1-carboxylic acid ethyl ester; (1S,3R)-1-Methyl-3-hydroxycyclobutane-1-carboxylate ethyl ester; (1S,3R)-3-Hydroxy-1-methylcyclobutyl-1-carboxylic acid ethyl ester; (1S,3R)-1-Methyl-3-hydroxycyclobutyl-1-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for chiral purity and chemical identity. Each batch is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC/MS to confirm stereochemical purity, chemical purity, and identity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess (e.e.), and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.