Description

(R)-Methyl 3,3-Difluorocyclopentanecarboxylate is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. This compound matters because its unique structure, featuring a difluorinated cyclopentane ring, is strategically used to modulate the physicochemical and metabolic properties of advanced molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a critical design strategy. The compound, CAS NO 1408057-37-3, is supplied to meet the stringent purity requirements of process chemistry and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in creating advanced, fluorinated active ingredients for crop protection with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty fluorinated polymers and advanced organic materials.
• Process Chemistry & Scale-Up: Provides a reliable starting point for the optimization and commercial-scale production of fluorinated target molecules.
• Medicinal Chemistry SAR Studies: Facilitates structure-activity relationship (SAR) studies by introducing a rigid, fluorinated cyclopentane moiety into lead compounds.

Basic Information

Item	Details
Product Name	(R)-Methyl 3,3-Difluorocyclopentanecarboxylate
CAS No.	1408057-37-3
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	(R)-Methyl 3,3-difluorocyclopentanecarboxylate; Methyl (1R)-3,3-difluorocyclopentanecarboxylate; (R)-3,3-Difluorocyclopentanecarboxylic acid methyl ester; (R)-Methyl 3,3-difluorocyclopentane-1-carboxylate; (1R)-3,3-Difluorocyclopentanecarboxylic Acid Methyl Ester; MFCD30566633; 1408057-37-3
EINECS	Contact for details

Quality Control

Every batch of (R)-Methyl 3,3-Difluorocyclopentanecarboxylate is produced under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, GC, and NMR, to ensure high enantiomeric excess (ee) and chemical purity critical for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.