Description

(S)-Methyl 3,3-Difluorocyclopentanecarboxylate is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. Its core value lies in the unique reactivity imparted by the difluorocyclopentane scaffold and the stereogenic center, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in medicinal chemistry for creating protease inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for targeting enzymes and receptors.
• Agrochemical Synthesis: Used in creating advanced, fluorinated active ingredients for crop protection with improved efficacy and environmental profile.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to modulate physicochemical properties like lipophilicity and metabolic stability.
• Protease Inhibitor Development: Serves as a core scaffold for synthesizing potential inhibitors for viral proteases (e.g., HCV, SARS-CoV-2) and other disease-related enzymes.
• Fluorine Chemistry Research: A valuable substrate for exploring new fluorination methodologies and studying the stereoelectronic effects of the gem-difluoro group.
• Advanced Material Precursor: Potential use in synthesizing specialty monomers or ligands for catalysts and functional materials.

Basic Information

Product Name	(S)-Methyl 3,3-Difluorocyclopentanecarboxylate
CAS No.	1408002-87-8
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	Methyl (1S)-3,3-difluorocyclopentanecarboxylate; (S)-Methyl 3,3-difluorocyclopentane-1-carboxylate; (1S)-3,3-Difluorocyclopentanecarboxylic acid methyl ester; (S)-3,3-Difluorocyclopentanecarboxylic Acid Methyl Ester; (S)-Methyl 3,3-difluorocyclopentylcarboxylate; (S)-Methyl 3,3-difluorocyclopentane carboxylate; MFCD31578966
EINECS	Contact for details

Quality Control

Our (S)-Methyl 3,3-Difluorocyclopentanecarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity, critical for sensitive pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and GC/MS for identity and purity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.