Description

tert-Butyl 2,6-Diazaspiro[4.5]decane-6-carboxylate hydrochloride is a high-purity, protected spirocyclic diamine building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, enabling the exploration of novel therapeutic agents. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing advanced molecular scaffolds with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to introduce constrained spirocyclic and diamine motifs, which can improve potency, selectivity, and metabolic stability.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein function.
• Agrochemical Research: Employed in the discovery and development of novel herbicides, fungicides, and insecticides that require sophisticated heterocyclic architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and advanced intermediates under cGMP conditions.
• Library Synthesis: Ideal for generating diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Product Name	tert-Butyl 2,6-Diazaspiro[4.5]decane-6-carboxylate hydrochloride
CAS No.	1407522-01-3
Molecular Formula	C13H25N2O2•HCl
Molecular Weight	276.81 g/mol (free base: 241.35 g/mol)
Synonyms	6-(tert-Butoxycarbonyl)-2,6-diazaspiro[4.5]decane hydrochloride; 2,6-Diazaspiro[4.5]decane-6-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; tert-Butyl 2,6-diazaspiro[4.5]decane-6-carboxylate HCl; 2,6-Diazaspiro[4.5]decane-6-carboxylate, tert-butyl ester, hydrochloride; Boc-2,6-diazaspiro[4.5]decane hydrochloride; 1407522-01-3; 1,1-Dimethylethyl 2,6-diazaspiro[4.5]decane-6-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,6-Diazaspiro[4.5]decane-6-carboxylate hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.