Description

tert-Butyl 4-(3-Bromo-5-Nitropyridin-4-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized pyridine-piperazine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of small molecule therapeutics, particularly in kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of targeted small molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive bromo and nitro functional groups.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and protein functions.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke chemical synthesis projects.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents.

Basic Information

Product Name	tert-Butyl 4-(3-Bromo-5-Nitropyridin-4-yl)piperazine-1-carboxylate
CAS No.	1407516-48-6
Molecular Formula	C14H19BrN4O4
Molecular Weight	387.23 g/mol
Synonyms	1-Boc-4-(3-bromo-5-nitropyridin-4-yl)piperazine; tert-Butyl 4-(3-bromo-5-nitro-4-pyridinyl)-1-piperazinecarboxylate; 4-Piperazinecarboxylic acid, 4-(3-bromo-5-nitro-4-pyridinyl)-, 1,1-dimethylethyl ester; BOC-4-(3-Bromo-5-Nitropyridin-4-yl)piperazine; 1407516-48-6; 3-Bromo-5-nitro-4-(1-piperazinyl)pyridine 1-Boc derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Bromo-5-Nitropyridin-4-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.