Description

Bococizumab CAS NO 1407495-02-6 is a high-purity, humanized monoclonal antibody designed to target and inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9). This compound is of significant interest for its role in lipid metabolism regulation and its potential therapeutic applications. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in cardiovascular disease research and novel biologic drug development.

Application

• Pharmaceutical R&D: Key intermediate or reference standard in the development of PCSK9 inhibitor therapies for managing hypercholesterolemia and reducing cardiovascular risk.
• Biochemical Research: Used as a critical tool to study the PCSK9-LDL receptor interaction, lipid homeostasis, and related metabolic pathways in vitro and in vivo.
• Clinical Trial Material: Serves as a non-clinical grade material for formulation studies, assay development, and preclinical pharmacokinetic/pharmacodynamic modeling.
• Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control testing of biologic drug substances.
• Antibody Engineering: Provides a template for studying humanization techniques, affinity maturation, and structure-activity relationships (SAR) of therapeutic antibodies.

Basic Information

Product Name	Bococizumab
CAS No.	1407495-02-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PF-04950615; RN-316; Anti-PCSK9 Monoclonal Antibody (RN316); Bococizumab (USAN/INN); PF 04950615; RN316; Humanized PCSK9 Antibody
EINECS	Contact for details

Quality Control

Our Bococizumab is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation, and bioburden testing, to ensure it meets the stringent requirements for research-grade biologics. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. Store in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Protein Content (UV)	≥ 90% of label claim
Endotoxin	< 1.0 EU/mg
Bioburden	To meet USP <61> guidelines
Solubility	Soluble in PBS or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.