Description

tert-Butyl 5-Propionyl-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially within oncology and CNS drug discovery pipelines.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its modifiable pyrrolopyridine core.
• Kinase Inhibitor Development: A key structural component in the research and synthesis of potential kinase inhibitors, leveraging its privileged heterocyclic architecture.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the custom production of specialized compounds for client research programs.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	tert-Butyl 5-Propionyl-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylate
CAS No.	1407180-80-6
Molecular Formula	C15H18N2O3
Molecular Weight	274.32 g/mol
Synonyms	1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 5-propionyl-, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-5-propionyl-1H-pyrrolo[3,2-b]pyridine; 5-Propionyl-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-propionylpyrrolo[3,2-b]pyridine-1-carboxylate; Boc-5-propionyl-pyrrolo[3,2-b]pyridine; 1407180-80-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Propionyl-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.