Description

3-Fluoro-1-Hydroxymethyl-Cyclobutanecarboxylic Acid Isopropyl Ester is a high-value, multifunctional cyclobutane derivative designed for advanced chemical synthesis. This compound is critical for research and development in pharmaceutical chemistry, serving as a versatile chiral building block for the creation of novel active pharmaceutical ingredients (APIs). It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require sophisticated intermediates with precise stereochemistry and functional group compatibility.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the cyclobutane scaffold and fluorine atom impart unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for producing specialty polymers with tailored thermal and mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Product Name	3-Fluoro-1-Hydroxymethyl-Cyclobutanecarboxylic Acid Isopropyl Ester
CAS No.	1403766-71-1
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	Isopropyl 3-Fluoro-1-(hydroxymethyl)cyclobutanecarboxylate; 1-(Hydroxymethyl)-3-fluorocyclobutanecarboxylic Acid Isopropyl Ester; 3-Fluoro-1-(hydroxymethyl)cyclobutanecarboxylic Acid 1-Methylethyl Ester; 3-Fluoro-1-Hydroxymethylcyclobutanecarboxylic Acid Isopropyl Ester; 1403766-71-1; 3-Fluoro-1-(hydroxymethyl)cyclobutanecarboxylate isopropyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-1-Hydroxymethyl-Cyclobutanecarboxylic Acid Isopropyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.