Description

5'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic indole scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutics, particularly in oncology and central nervous system (CNS) disorders. Our supply ensures the high purity and batch-to-batch consistency required for sensitive R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small molecule drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Used in university and institutional labs for exploratory synthetic and pharmacological studies.

Basic Information

Product Name	5'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1403566-81-3
Molecular Formula	C10H8ClNO
Molecular Weight	193.63 g/mol
Synonyms	5'-Chloro-1'H-spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 5'-Chloro-1'H-spiro[cyclopropane-1,3'-indole]-2'-one; 1'H-Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-chloro-; 5-Chlorospiro[cyclopropane-1,3'-indolin]-2'-one; Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-chloro-; 1403566-81-3
EINECS	Contact for details

Quality Control

Our 5'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with full chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.