Description

7'-Chlorospiro[Cyclopropane-1,3'-Indolin]-2'-One is a high-value, synthetically versatile spirocyclic oxindole derivative. This compound serves as a critical pharmaceutical intermediate and a privileged scaffold in modern medicinal chemistry for the development of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical R&D departments engaged in drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates with spirocyclic architectures.
• Medicinal Chemistry Research: Core scaffold for constructing compound libraries to screen for biological activity against various disease targets.
• Kinase Inhibitor Development: Used in the research and synthesis of small molecule inhibitors for cancer and other proliferative diseases.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.

Basic Information

Product Name	7'-Chlorospiro[Cyclopropane-1,3'-Indolin]-2'-One
CAS No.	1403564-65-7
Molecular Formula	C10H8ClNO
Molecular Weight	193.63 g/mol
Synonyms	7'-Chloro-1'H-spiro[cyclopropane-1,3'-indolin]-2'-one; 7'-Chlorospiro[cyclopropane-1,3'-indolin]-2'-one; Spiro[cyclopropane-1,3'-indolin]-2'-one, 7'-chloro-; 7-Chlorospiro[cyclopropane-1,3'-indolin]-2'-one; 7'-Chloro-spiro[cyclopropane-1,3'-indole]-2-one; 1403564-65-7; 7'-Chloro-1'H-spiro[cyclopropane-1,3'-indole]-2'(3'H)-one
EINECS	Contact for details

Quality Control

Our 7'-Chlorospiro[Cyclopropane-1,3'-Indolin]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.