Description

Azido-Peg5-Succinimidyl Carbonate is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive NHS ester and a terminal azide group for click chemistry. This compound is essential for creating stable, biocompatible conjugates between biomolecules and surfaces or other molecules. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and materials science for applications like drug delivery system assembly and surface functionalization.

Application

• Bioconjugation and Linker Chemistry: Used to covalently link amines (from proteins, peptides, antibodies) to alkyne-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• ADC (Antibody-Drug Conjugate) Development: Serves as a key building block for constructing PEGylated linkers that connect cytotoxic payloads to monoclonal antibodies.
• Surface Modification and Functionalization: Enables the "clickable" PEGylation of nanoparticles, biosensors, microarrays, and other material surfaces to improve biocompatibility and introduce specific functionalities.
• Polymer and Hydrogel Synthesis: Acts as a crosslinking agent in the synthesis of PEG-based hydrogels and smart polymers for biomedical applications.
• Diagnostic Reagent Preparation: Utilized in the development of diagnostic assays and imaging probes by conjugating targeting ligands with reporter molecules.
• Peptide and Protein PEGylation: Facilitates site-specific PEGylation to enhance the pharmacokinetic properties, solubility, and stability of therapeutic peptides and proteins.

Basic Information

Product Name	Azido-Peg5-Succinimidyl Carbonate
CAS No.	1402411-88-4
Molecular Formula	C24H40N4O12
Molecular Weight	576.60 g/mol
Synonyms	NHS-PEG5-Azide; Azido-PEG5-NHS ester; N-(Azido-PEG5)-N-hydroxysuccinimide carbonate; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propyl carbonate; 5k-PEG-NHS ester, Azide terminated; PEG-Azide NHS Ester (MW 576); Azido-Pentaethylene glycol NHS Carbonate; N-Succinimidyl Carbonate-PEG5-Azide
EINECS	Contact for details

Quality Control

Our Azido-Peg5-Succinimidyl Carbonate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for research and bioconjugation applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen) and allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (NHS Ester)	≥ 90% of theoretical
Solubility	Soluble in DMF, DMSO, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.