Description

2-Methyl-2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propanenitrile is a specialized organoboron building block featuring a protected boronic ester group and a cyano moiety. This compound is critical for facilitating efficient cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key pyridine-containing boronic ester reagent for constructing biaryl and heterobiaryl systems in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing substituted pyridine cores.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science & OLED Development: Acts as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in OLEDs.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for bio-conjugation and imaging applications.
• Process Chemistry & Scale-up: Provides a stable, handleable boronate source for optimizing large-scale synthetic routes in fine chemical production.

Basic Information

Product Name	2-Methyl-2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propanenitrile
CAS No.	1402390-59-3
Molecular Formula	C15H21BN2O2
Molecular Weight	272.15 g/mol
Synonyms	2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-2-methylpropanenitrile; 2-Methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)propanenitrile; 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]-2-methylpropionitrile; Propanenitrile, 2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-cyano-2-propyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.