Description

7'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique spiro[piperidine-4,3'-quinoline] scaffold.
• API Synthesis: Serves as a core building block in the multi-step synthesis of complex target molecules for preclinical and clinical trials.
• CNS Drug Development: Particularly relevant for projects focusing on modulators of neurotransmitter systems, given the structural motifs present.
• Oncology Research: Potential utility in the synthesis of compounds designed to interact with specific biological targets in cancer pathways.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Academic & Institutional Research: Used in universities and research institutes for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	7'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid
CAS No.	1402233-02-6
Molecular Formula	C13H14FN2O·HCl
Molecular Weight	268.72 g/mol (Free base: 232.26 g/mol)
Synonyms	7'-Fluoro-2',4'-dihydro-1'H-spiro[piperidine-4,3'-quinoline]-2'-one hydrochloride; Spiro[piperidine-4,3'-quinoline]-2'-one, 7'-fluoro-2',4'-dihydro-, hydrochloride; 7-Fluoro-2,4-dihydrospiro[quinoline-3,4'-piperidine]-2-one hydrochloride; 7'-Fluoro-1'H-spiro[piperidine-4,3'-quinoline]-2'(4'H)-one hydrochloride; CAS 1402233-02-6; 7'-F-Spiroquinolinone hydrochloride
EINECS	Contact for details

Quality Control

Our 7'-Fluoro-2',4'-Dihydro-1'H-Spiro[Piperidine-4,3'-Quinoline]-2'-One Hydrochlorid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.