Description

trans-1,3-Cyclobutanedicarboxylic Acid 1-Methyl Ester CAS NO 1401103-71-6 is a high-purity, functionalized cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its rigid, strained four-membered ring structure and strategically positioned ester functionality make it a valuable scaffold for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the cyclobutane core can impart unique biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers with tailored thermal and mechanical properties.
• Chemical Biology Probes: Utilized as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Academic & Industrial R&D: A versatile building block for method development and exploring new chemical space in synthetic organic chemistry laboratories.

Basic Information

Product Name	trans-1,3-Cyclobutanedicarboxylic Acid 1-Methyl Ester
CAS No.	1401103-71-6
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(1R,3S)-1,3-Cyclobutanedicarboxylic Acid 1-Methyl Ester; (1S,3R)-1,3-Cyclobutanedicarboxylic Acid 1-Methyl Ester; Methyl (1R,3S)-1,3-Cyclobutanedicarboxylate; Methyl (1S,3R)-1,3-Cyclobutanedicarboxylate; trans-Methyl 3-Carboxycyclobutanecarboxylate; trans-1,3-Cyclobutanedicarboxylic Acid Monomethyl Ester; 1-Methyl trans-1,3-Cyclobutanedicarboxylate
EINECS	Contact for details

Quality Control

Our trans-1,3-Cyclobutanedicarboxylic Acid 1-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.