Description

(R)-2-(2-tert-Butoxy-2-Oxoethyl)-5,5,5-Trifluoropentanoic Acid CAS NO 1401067-08-0 is a high-purity, chiral fluorinated carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise stereochemistry and the unique reactivity imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced properties. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially those targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluorine moiety improves biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Peptidomimetics & Bioactive Molecules: Integral for constructing fluorinated amino acid analogs and other bioactive molecules in medicinal chemistry.

Basic Information

Item	Details
Product Name	(R)-2-(2-tert-Butoxy-2-Oxoethyl)-5,5,5-Trifluoropentanoic Acid
CAS No.	1401067-08-0
Molecular Formula	C11H17F3O4
Molecular Weight	270.25 g/mol
Synonyms	(R)-5,5,5-Trifluoro-2-(2-((tert-butoxy)carbonyl)ethyl)pentanoic acid; (R)-2-(2-(tert-Butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid; (R)-2-(2-tert-Butoxy-2-oxo-ethyl)-5,5,5-trifluoro-pentanoic acid; (R)-α-(2-tert-Butoxy-2-oxoethyl)-5,5,5-trifluorovaleric acid; (2R)-2-[2-(tert-Butoxy)-2-oxoethyl]-5,5,5-trifluoropentanoic acid; Chiral Trifluoromethylated Acid Ester Derivative; tert-Butyl (R)-3-(3,3,3-trifluoropropyl)succinate (acid form)
EINECS	Contact for details

Quality Control

Our (R)-2-(2-tert-Butoxy-2-Oxoethyl)-5,5,5-Trifluoropentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee reproducible results and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.