Description

4H-Cyclopenta-1,3-Dioxol-4-Amine, 6-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethoxy]Tetrahydro-2,2-Dimethyl-, (3As,4R,6S,6Ar)- is a sophisticated, high-purity chemical intermediate featuring a protected amine and silyl ether functionality. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical and biotechnology R&D teams for developing new active pharmaceutical ingredients (APIs), particularly in nucleoside and carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel antiviral and anticancer therapeutics.
• Nucleoside Analogue Synthesis: Used in constructing modified nucleosides for potential drug candidates targeting viral polymerases.
• Carbohydrate Chemistry: Serves as a protected glycosyl donor or acceptor precursor in the synthesis of complex oligosaccharides.
• Pro-drug Development: Employed to introduce protective groups that enhance the stability, solubility, or bioavailability of drug molecules.
• Chemical Biology Research: Utilized as a tool compound for studying enzyme mechanisms or as a scaffold for library synthesis in medicinal chemistry.
• Process Chemistry: Acts as a standardized, high-quality starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Item	Detail
Product Name	4H-Cyclopenta-1,3-Dioxol-4-Amine, 6-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethoxy]Tetrahydro-2,2-Dimethyl-, (3As,4R,6S,6Ar)-
CAS No.	1400665-85-1
Molecular Formula	C16H33NO4Si
Molecular Weight	331.53 g/mol
Synonyms	(3aS,4R,6S,6aR)-6-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-amine; 4-Amino-6-O-(2-(tert-butyldimethylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde Acetal; Protected Isopropylidene Ribofuranosylamine Derivative; TBDMS-protected Amino Dioxolane; CAS 1400665-85-1; Amino Dioxolane Silyl Ether; Chiral Cyclopentadioxolane Amine Intermediate
EINECS	Contact for details

Quality Control

Our 4H-Cyclopenta-1,3-Dioxol-4-Amine derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material that meets the stringent requirements for pharmaceutical development, including specifications for chiral purity and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.