Description

1,3-Dimethyl 2-(2,3-Difluoro-6-Nitrophenyl)Propanedioate is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluoro-nitrophenyl substitution pattern. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients. Its precise structure offers a strategic handle for further functionalization in multi-step synthetic routes.

Application

This specialized intermediate is designed for high-value synthetic applications. Its primary and potential uses include:

• Pharmaceutical Intermediate: A critical precursor in the research and development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Serves as a building block for creating new herbicides, fungicides, or insecticides where the difluoro and nitro groups impart specific biological activity.
• Organic Synthesis & Research: Used in academic and industrial R&D for constructing complex heterocyclic compounds or as a model substrate in methodological studies.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals or functional materials requiring its unique aromatic structure.

Basic Information

Product Name	1,3-Dimethyl 2-(2,3-Difluoro-6-Nitrophenyl)Propanedioate
CAS No.	1400644-66-7
Molecular Formula	C13H11F2NO6
Molecular Weight	315.23 g/mol
Synonyms	Dimethyl 2-(2,3-difluoro-6-nitrophenyl)malonate; Propanedioic acid, 2-(2,3-difluoro-6-nitrophenyl)-, 1,3-dimethyl ester; 2-(2,3-Difluoro-6-nitrophenyl)malonic acid dimethyl ester; Dimethyl (2,3-difluoro-6-nitrobenzyl)malonate; CAS 1400644-66-7
EINECS	Contact for details

Quality Control

Our production of 1,3-Dimethyl 2-(2,3-Difluoro-6-Nitrophenyl)Propanedioate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and reliable supply chain integrity makes us a trusted partner for your critical intermediate needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.