Description

4-Ethynyl-1-(2,2,2-Trifluoroethyl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block featuring both a pyrazole ring and a terminal alkyne group. This compound is critical for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Click Chemistry Reagent: The terminal alkyne moiety enables efficient Huisgen 1,3-dipolar cycloaddition (click chemistry) for bioconjugation, polymer modification, and material surface functionalization.
• Ligand Synthesis: Serves as a precursor for creating novel nitrogen-containing ligands used in catalysis and coordination chemistry.
• Material Science: Incorporated into the synthesis of advanced polymers, metal-organic frameworks (MOFs), and functional materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	4-Ethynyl-1-(2,2,2-Trifluoroethyl)-1H-Pyrazole
CAS No.	1400287-67-3
Molecular Formula	C7H5F3N2
Molecular Weight	174.12 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-4-ethynyl-1H-pyrazole; 4-Ethynyl-1-(2,2,2-trifluoroethyl)pyrazole; 4-Ethynyl-1-(trifluoroethyl)pyrazole; 1H-Pyrazole, 4-ethynyl-1-(2,2,2-trifluoroethyl)-; 4-Ethynyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole; 1400287-67-3 (CAS)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.