Description

5'-Amino-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors due to the indole-based structural motif.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological mechanisms and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical innovation pipelines.

Basic Information

Product Name	5'-Amino-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1399663-06-9
Molecular Formula	C10H10N2O
Molecular Weight	174.20 g/mol
Synonyms	2'-Oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-amine; 5'-Amino-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one; 5-Amino-1,2-dihydrospiro[cyclopropane-1,3'-indole]-2'-one; Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-amino-1',2'-dihydro-; 1399663-06-9
EINECS	Contact for details

Quality Control

Our 5'-Amino-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.