Description

5'-Nitro-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought after by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those exploring spirocyclic and indole-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities with potential biological activity.
• API Development: Serves as a building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Academic & Institutional R&D: Employed in university and research institute laboratories for exploratory synthetic chemistry and novel compound library generation.

Basic Information

Product Name	5'-Nitro-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1399654-82-0
Molecular Formula	C10H8N2O3
Molecular Weight	204.18 g/mol
Synonyms	5'-Nitrospiro[cyclopropane-1,3'-indolin]-2'-one; 2'-Oxo-1',2'-dihydro-5'-nitrospiro[cyclopropane-1,3'-indole]; 5'-Nitro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one; Spiro[cyclopropane-1,3'-indole]-2'-one, 5'-nitro-1',2'-dihydro-; 1399654-82-0; 5-Nitrospiro[cyclopropane-1,3'-indolin]-2'-one
EINECS	Contact for details

Quality Control

Our 5'-Nitro-1',2'-Dihydrospiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.