Description

1'-Benzyl-5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing who require reliable, high-quality intermediates to accelerate drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic and halogenated structure.
• Process Chemistry & Scale-up: Serves as a defined starting material or intermediate for the GMP-compliant synthesis of target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and methodology development.
• Library Synthesis: Employed for the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Detail
Product Name	1'-Benzyl-5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One
CAS No.	1399183-27-7
Molecular Formula	C20H20BrNO2
Molecular Weight	386.29 g/mol
Synonyms	5-Bromo-1'-benzylspiro[isobenzofuran-1(3H),4'-piperidin]-3-one; 1'-Benzyl-5-bromospiro[isobenzofuran-1(3H),4'-piperidin]-3-one; 5-Bromo-1'-(phenylmethyl)spiro[2-benzofuran-1(3H),4'-piperidine]-3-one; Spiro[isobenzofuran-1(3H),4'-piperidine]-3-one, 5-bromo-1'-(phenylmethyl)-; 1399183-27-7; 5-Bromo-1'-benzyl-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one
EINECS	Contact for details

Quality Control

Our 1'-Benzyl-5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and stringent in-process controls guarantees a reliable supply of this high-value intermediate for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.