Description

4-Chloro-5-Iodo-2-Methyl-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic ester building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chlorine and iodine substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as drug discovery and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the halogenated benzoate structure imparts specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Organic Synthesis Building Block: Employed in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Chloro-5-Iodo-2-Methyl-Benzoic Acid Methyl Ester
CAS No.	1399182-04-7
Molecular Formula	C9H8ClIO2
Molecular Weight	310.52 g/mol
Synonyms	Methyl 4-Chloro-5-iodo-2-methylbenzoate; 2-Methyl-4-chloro-5-iodobenzoic Acid Methyl Ester; Benzoic acid, 4-chloro-5-iodo-2-methyl-, methyl ester; 4-Chloro-5-iodo-o-toluic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-2-Methyl-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.