Description

Spiro[Azetidine-3,1'(3'H)-Isobenzofuran]-1-Carboxylic Acid, 5'-Acetyl-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. Its complex, rigid molecular architecture makes it a valuable intermediate for constructing novel pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its spirocyclic structure for enhanced biological activity and stability.
• Chemical Biology Probe: Acts as a scaffold for creating molecular probes to study enzyme function and protein-protein interactions.
• Material Science: Investigated as a monomer or additive for creating polymers with unique thermal and mechanical properties.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in stereoselective synthesis.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and the exploration of new chemical space.

Basic Information

Item	Details
Product Name	Spiro[Azetidine-3,1'(3'H)-Isobenzofuran]-1-Carboxylic Acid, 5'-Acetyl-, 1,1-Dimethylethyl Ester
CAS No.	1398609-81-8
Molecular Formula	C17H19NO4
Molecular Weight	301.34 g/mol
Synonyms	tert-Butyl 5'-acetylspiro[azetidine-3,1'-isobenzofuran]-1-carboxylate; 5'-Acetylspiro[azetidine-3,1'-isobenzofuran]-1-carboxylic acid tert-butyl ester; Spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-carboxylic acid, 5'-acetyl-, 1,1-dimethylethyl ester; 1398609-81-8; tert-Butyl 5-acetylspiro[azetidine-3,1'-isobenzofuran]-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of Spiro[Azetidine-3,1'(3'H)-Isobenzofuran]-1-Carboxylic Acid, 5'-Acetyl-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols suitable for research and development applications. Every batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters is provided with each shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.