Description

tert-Butyl 5'-Bromo-3'H-Spiro[Azetidine-3,1'-[2]Benzofuran]-1-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic architecture. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Serves as a critical starting material for optimizing scalable synthetic routes to potential APIs.
• Spirocyclic Compound Synthesis: Exploited for constructing challenging spiro-fused heterocyclic systems of high interest in modern drug design.
• Brominated Building Block: The bromo substituent provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	tert-Butyl 5'-Bromo-3'H-Spiro[Azetidine-3,1'-[2]Benzofuran]-1-Carboxylate
CAS No.	1398609-80-7
Molecular Formula	C15H18BrNO3
Molecular Weight	340.21 g/mol
Synonyms	1-(1,1-Dimethylethyl) 5'-Bromo-3'H-Spiro[Azetidine-3,1'-[2]Benzofuran]-1-Carboxylate; tert-Butyl 5'-Bromospiro[azetidine-3,1'-isobenzofuran]-1-carboxylate; 5'-Bromo-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylic acid tert-butyl ester; Boc-Protected 5'-Bromospiroazetidine Benzofuran; 1398609-80-7; Azetidine-1-carboxylic acid, 5'-bromo-3'H-spiro[azetidine-3,1'-[2]benzofuran]-1-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical specifications. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.