Description

(S)-7-Amino-5-(4-Methoxybenzyl)-5-Azaspiro[2.4]Heptan-4-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly those targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex, bioactive molecules.

Application

• Key Intermediate in Drug Discovery: Serves as a critical building block for the synthesis of potential drug candidates, especially in neuroscience and psychiatric disorder research.
• Pharmacological Research: Used in the study of structure-activity relationships (SAR) and the development of compounds with specific receptor binding profiles.
• Spirocyclic Compound Synthesis: Its rigid spiro[2.4]heptane scaffold is valuable for creating conformationally constrained analogs to improve metabolic stability and potency.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material (CTM) production.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(S)-7-Amino-5-(4-Methoxybenzyl)-5-Azaspiro[2.4]Heptan-4-One
CAS No.	1398507-72-6
Molecular Formula	C15H20N2O2
Molecular Weight	260.34 g/mol
Synonyms	(S)-7-Amino-5-(4-methoxybenzyl)-5-azaspiro[2.4]heptan-4-one; 5-Azaspiro[2.4]heptan-4-one, 7-amino-5-[(4-methoxyphenyl)methyl]-, (7S)-; (7S)-7-Amino-5-[(4-methoxyphenyl)methyl]-5-azaspiro[2.4]heptan-4-one; UNII-9K8V7EKI5T; 9K8V7EKI5T; Spiro[2.4]heptane derivative; (S)-enantiomer of 7-Amino-5-(4-methoxybenzyl)-5-azaspiro[2.4]heptan-4-one
EINECS	Contact for details

Quality Control

Our production of (S)-7-Amino-5-(4-Methoxybenzyl)-5-Azaspiro[2.4]Heptan-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material manufactured under quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.