Description

Avadomide Hydrochloride is a high-purity, small molecule pharmaceutical intermediate and research compound. It serves as a critical building block in the development of novel immunomodulatory drugs and targeted protein degraders, known as Cereblon E3 Ligase Modulating Drugs (CELMoDs). This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on oncology, autoimmune disorders, and other therapeutic areas requiring precise molecular intervention.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of next-generation immunomodulatory imide drug (IMiD) candidates.
• Biomedical Research: Used as a reference standard and active agent in in vitro and in vivo studies to investigate Cereblon-dependent protein degradation pathways.
• Drug Discovery & Development: A vital tool for high-throughput screening (HTS) and structure-activity relationship (SAR) studies in oncology and immunology research programs.
• Preclinical Studies: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology evaluations of novel therapeutic agents.
• API Synthesis: Used in the controlled-scale manufacturing of Active Pharmaceutical Ingredients (APIs) for clinical trial materials.
• Academic Research: Supports fundamental research in chemical biology, particularly in understanding targeted protein degradation mechanisms.

Basic Information

Product Name	Avadomide Hydrochloride
CAS No.	1398053-45-6
Molecular Formula	C₁₄H₁₃ClN₂O₃ • HCl
Molecular Weight	329.18 g/mol
Synonyms	CC-122 Hydrochloride; (S)-3-(4-((4-Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride; Avadomide HCl; CC122 Hydrochloride; 2,6-Piperidinedione, 3-[4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]-, hydrochloride (1:1), (3S)-
EINECS	Contact for details

Quality Control

Our Avadomide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identity confirmation (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.