Description

2-(Azido-Peg2-Amido)-1,3-Bis-(tert-Butyldimethylsilanoxy)Propane is a specialized bifunctional chemical building block featuring an azide group and silyl-protected diols, connected by a polyethylene glycol (PEG) spacer. This compound is engineered to facilitate controlled conjugation and bioconjugation strategies, offering orthogonal reactivity for click chemistry applications. It is a critical intermediate for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise, modular molecular assembly.

Application

• Bioconjugation and Linker Chemistry: Serves as a heterobifunctional crosslinker for attaching biomolecules (e.g., peptides, antibodies, oligonucleotides) to surfaces, polymers, or other molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical Intermediate: Used in the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutic agents where controlled release and solubility enhancement are required.
• Polymer and Dendrimer Synthesis: Acts as a functional monomer or chain extender for creating PEGylated polymers, hydrogels, and dendritic structures with tailored properties.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and diagnostic assay substrates with bio-recognition elements.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) groups protect hydroxyl functionalities during multi-step synthetic sequences, which can be selectively deprotected under mild conditions.
• Chemical Probe Development: Utilized in creating activity-based probes for studying enzyme function and metabolic pathways in chemical biology.

Basic Information

Product Name	2-(Azido-Peg2-Amido)-1,3-Bis-(tert-Butyldimethylsilanoxy)Propane
CAS No.	1398044-56-8
Molecular Formula	C22H48N4O5Si2
Molecular Weight	528.81 g/mol
Synonyms	2-(2-(2-Azidoethoxy)ethoxy)acetamido-1,3-propanediol bis(TBDMS ether); 1,3-Bis-O-(tert-butyldimethylsilyl)-2-[2-[2-(2-azidoethoxy)ethoxy]acetamido]propane; Azido-PEG2-TBDMS-protected glycerol; N-(3,5-Bis-O-(tert-butyldimethylsilyl)-2-hydroxypropyl)-2-(2-(2-azidoethoxy)ethoxy)acetamide; Heterobifunctional PEG linker, Azido-PEG2-amide-TBDMS glycerol; TBDMS-protected azido-PEG2-glycerol derivative
EINECS	Contact for details

Quality Control

Our 2-(Azido-Peg2-Amido)-1,3-Bis-(tert-Butyldimethylsilanoxy)Propane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, HPLC, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The compound is moisture-sensitive (hygroscopic) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H NMR, 13C NMR)
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.