Description

2-(Azido-Peg2-Amido)-1,3-Propandiol is a specialized bifunctional PEG derivative featuring a terminal azide group and a diol moiety, making it a versatile click chemistry reagent and linker. This compound is essential for the controlled, site-specific conjugation of biomolecules and polymers, enabling the development of advanced drug delivery systems and functional materials. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for creating targeted therapeutics, diagnostic probes, and smart hydrogels.

Application

• Bioconjugation and Click Chemistry: Acts as a heterobifunctional crosslinker for the azide-alkyne cycloaddition (CuAAC or SPAAC) modification of peptides, proteins, and oligonucleotides.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key building block for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Polymer Functionalization: Used to introduce azide handles onto polymer backbones (e.g., PLGA, PEG) for subsequent grafting of targeting ligands or imaging agents.
• Surface Modification: Enables the biofunctionalization of nanoparticles, quantum dots, and biosensor surfaces to enhance targeting and biocompatibility.
• Hydrogel Synthesis: Participates in the formation of crosslinked networks for 3D cell culture scaffolds and controlled-release matrices.
• Prodrug Synthesis: Facilitates the design of prodrugs where the active pharmaceutical ingredient is released upon specific biological triggers.

Basic Information

Product Name	2-(Azido-Peg2-Amido)-1,3-Propandiol
CAS No.	1398044-52-4
Molecular Formula	C11H21N5O5
Molecular Weight	303.32 g/mol
Synonyms	2-[2-[2-(2-Azidoethoxy)ethoxy]acetamido]-1,3-propanediol; Azido-PEG2-C2-amido-1,3-propanediol; 1,3-Propanediol, 2-[[2-[2-(2-azidoethoxy)ethoxy]acetyl]amino]-; N-(2,3-Dihydroxypropyl)-2-[2-(2-azidoethoxy)ethoxy]acetamide; Azido-PEG2-acid amide of 2-Amino-1,3-propanediol; Heterobifunctional PEG Azide Diol; Click Chemistry PEG Linker
EINECS	Contact for details

Quality Control

Our 2-(Azido-Peg2-Amido)-1,3-Propandiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. The compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.