Description

1-(2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Pyridin-4-Yl)Propan-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethyl-substituted pyridine scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by R&D teams in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the metabolically stable trifluoromethyl group, which can improve a molecule's lipophilicity, bioavailability, and binding affinity.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Employed in the design and synthesis of chemical probes for studying biological pathways and target validation in early-stage drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of client-specific molecules under cGMP conditions.

Basic Information

Product Name	1-(2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Pyridin-4-Yl)Propan-2-One
CAS No.	1396893-39-2
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	2-(1,1,1-Trifluoro-2-methylpropan-2-yl)-4-propan-2-onylpyridine; 1-[2-(1,1,1-Trifluoro-2-methylpropan-2-yl)pyridin-4-yl]propan-2-one; 4-Propan-2-onyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine; 2-(1,1,1-Trifluoro-2-methyl-2-propyl)-4-(1-oxopropyl)pyridine; 1-(2-(1,1,1-Trifluoro-2-methylpropan-2-yl)pyridin-4-yl)acetone; TFMP-Pyridinone Intermediate
EINECS	Contact for details

Quality Control

Our 1-(2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Pyridin-4-Yl)Propan-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.