Description

Ethyl 6-Bromo-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a versatile building block for synthesizing novel, biologically active molecules, particularly in the fields of oncology and targeted therapies. It is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel pyrazolopyridine-based active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Core scaffold for research and production of potential therapeutic agents targeting specific kinases involved in cancer and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for creating specialized probes in biological assays.

Basic Information

Product Name	Ethyl 6-Bromo-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate
CAS No.	1396779-99-9
Molecular Formula	C12H12BrN3O2
Molecular Weight	310.15 g/mol
Synonyms	6-Bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester; Ethyl 6-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-bromo-3-methyl-, ethyl ester; 1396779-99-9; 6-Bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-Bromo-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for critical pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA), including HPLC purity, NMR, and mass spectrometry confirmation, is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.