Description

Spiro[Cyclopropane-1,4'(1'H)-Isoquinolin]-1'-One, 6'-Bromo-2',3'-Dihydro- is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and brominated isoquinoline structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential warhead or linker component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Employed in the construction of novel kinase inhibitor libraries for high-throughput screening.
• Chemical Biology Probes: Utilized to create tool compounds for investigating enzyme function and cellular signaling mechanisms.
• Academic Research: Supports synthetic organic chemistry and pharmacology studies in university and institutional laboratories.

Basic Information

Product Name	Spiro[Cyclopropane-1,4'(1'H)-Isoquinolin]-1'-One, 6'-Bromo-2',3'-Dihydro-
CAS No.	1396777-75-5
Molecular Formula	C₁₂H₁₀BrNO
Molecular Weight	264.12 g/mol
Synonyms	6'-Bromo-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinolin]-1'-one; 6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1'-one; 1396777-75-5; Spiro[cyclopropane-1,4'(1'H)-isoquinolin]-1'-one, 6'-bromo-2',3'-dihydro-; 6-Bromo-2,3-dihydrospiro[cyclopropane-1,4-isoquinolin]-1-one; 6'-Bromo-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinoline]-1'-one
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,4'(1'H)-Isoquinolin]-1'-One, 6'-Bromo-2',3'-Dihydro- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.