Description

2-Ethynyl-5-Methyl-Pyridin-3-Amine is a specialized pyridine derivative featuring an ethynyl substituent, serving as a high-value building block in advanced organic synthesis. Its unique structure makes it a critical intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, leveraging its pyridine core for biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in creating labeled compounds and probes for studying biological pathways and target engagement.
• Catalyst Ligand Development: Acts as a precursor for synthesizing novel ligand systems in homogeneous catalysis.
• Academic & Contract Research: Essential reagent for methodological development and exploratory chemistry in university and CRO laboratories.

Basic Information

Product Name	2-Ethynyl-5-Methyl-Pyridin-3-Amine
CAS No.	1394319-72-2
Molecular Formula	C8H8N2
Molecular Weight	132.16 g/mol
Synonyms	3-Amino-2-ethynyl-5-methylpyridine; 5-Methyl-2-ethynylpyridin-3-amine; 2-Ethynyl-5-methyl-3-pyridinamine; 2-Ethynyl-5-methyl-3-aminopyridine; 3-Pyridinamine, 2-ethynyl-5-methyl-; 2-Ethynyl-5-methylpyridin-3-ylamine; 5-Methyl-2-ethynyl-3-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-5-Methyl-Pyridin-3-Amine is produced under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic and easily oxidized nature, the container must be kept sealed and allowed to reach ambient temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.