Description

3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol is a high-value organosilicon-protected cyclobutane derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its primary commercial value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and specialty chemicals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, structurally defined intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Intermediate in the development of specialty polymers and advanced organic electronic materials with tailored properties.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of fine chemicals.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol
CAS No.	1394119-83-5
Molecular Formula	C12H26O2Si
Molecular Weight	230.42 g/mol
Synonyms	3-((tert-Butyldimethylsilyl)oxy)cyclobutanemethanol; Cyclobutanemethanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 3-(tert-Butyldimethylsiloxy)cyclobutanemethanol; 3-(TBDMS-oxy)cyclobutanemethanol; 3-Hydroxycyclobutylmethyl tert-butyldimethylsilyl ether; TBDMS ether of 3-(hydroxymethyl)cyclobutanol
EINECS	Contact for details

Quality Control

Our production of 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. All materials are subjected to comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We operate under a quality system aligned with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.