Description

6-Chloro-1,4-Dihydro-2H-[2,7]Naphthyridin-3-One is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Synthesis: Serves as a core scaffold for constructing complex molecules in active pharmaceutical ingredient manufacturing.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-1,4-Dihydro-2H-[2,7]Naphthyridin-3-One
CAS No.	1393558-33-2
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	6-Chloro-1,4-dihydro-2H-[2,7]naphthyridin-3-one; 6-Chloro-3,4-dihydro-1H-[2,7]naphthyridin-2-one; 6-Chloro-2,3-dihydro-1H-[2,7]naphthyridin-4-one; 1393558-33-2; 6-Chloro-1,4-dihydro-2H-[2,7]naphthyridin-3(4H)-one; 6-Chloro-3,4-dihydro-2H-[2,7]naphthyridin-1-one; 6-Chloro-2H-[2,7]naphthyridin-1,4-dihydro-3-one
EINECS	Contact for details

Quality Control

Our 6-Chloro-1,4-Dihydro-2H-[2,7]Naphthyridin-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.