Description

Methyl (4-Chlorophenyl)(Difluoro)Acetate is a high-value fluorinated building block essential for advanced organic synthesis. This compound is prized for its role in introducing the difluoroacetate moiety, a key functional group that can modulate the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoroacetate group can enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialty polymers and liquid crystals with unique electronic or optical properties.
• Fluorine Chemistry Research: An important reagent in academic and industrial laboratories focused on exploring new C-F bond formation reactions and fluorination methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Methyl (4-Chlorophenyl)(Difluoro)Acetate
CAS No.	1393558-32-1
Molecular Formula	C9H7ClF2O2
Molecular Weight	220.60 g/mol
Synonyms	Methyl 2-(4-Chlorophenyl)-2,2-difluoroacetate; 2-(4-Chlorophenyl)-2,2-difluoroacetic Acid Methyl Ester; (4-Chlorophenyl)difluoroacetic Acid Methyl Ester; Methyl 4-Chloro-α,α-difluorophenylacetate; Difluoro(4-chlorophenyl)acetic Acid Methyl Ester; Methyl α,α-Difluoro-4-chlorophenylacetate
EINECS	Contact for details

Quality Control

Every batch of Methyl (4-Chlorophenyl)(Difluoro)Acetate is manufactured under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.