Description

4-Chloro-3-Fluoropyridin-2-Amine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Used in the development of organic electronic materials, ligands for catalysis, and advanced polymers.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for custom synthesis projects and scale-up development.

Basic Information

Product Name	4-Chloro-3-Fluoropyridin-2-Amine
CAS No.	1393553-69-9
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	2-Amino-4-chloro-3-fluoropyridine; 3-Fluoro-4-chloropyridin-2-amine; 4-Chloro-3-fluoro-2-pyridinamine; 4-Chloro-3-fluoropyridine-2-amine; 2-Pyridinamine, 4-chloro-3-fluoro-; 1393553-69-9
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoropyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.