Description

tert-Butyl (S)-(1,1,1-Trifluoro-3-Hydroxypropan-2-Yl)Carbamate is a high-purity, chiral building block featuring a trifluoromethyl group and a protected amino alcohol moiety. This compound is critical for introducing fluorine atoms and specific stereochemistry into target molecules, which can dramatically alter their metabolic stability, lipophilicity, and binding affinity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Fluorine Chemistry Research: Serves as a valuable substrate for studying fluorination reactions and the effects of fluorine substitution on molecular properties in medicinal and materials chemistry.
• Peptidomimetics & PROTACs: Employed in the construction of peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its orthogonal protecting groups and defined stereocenter.
• Ligand & Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	tert-Butyl (S)-(1,1,1-Trifluoro-3-Hydroxypropan-2-Yl)Carbamate
CAS No.	1393524-00-9
Molecular Formula	C9H16F3NO3
Molecular Weight	243.22 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3,3,3-trifluoropropan-1-ol; (S)-N-Boc-3,3,3-trifluoroalaninol; (S)-3,3,3-Trifluoro-2-((tert-butoxycarbonyl)amino)-1-propanol; Boc-(S)-3,3,3-trifluoroalaninol; (S)-2-(Boc-amino)-3,3,3-trifluoropropanol; tert-Butyl N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]carbamate; (S)-Boc-Amino(3,3,3-trifluoro)propanol
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-(1,1,1-Trifluoro-3-Hydroxypropan-2-Yl)Carbamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess, NMR, and mass spectrometry for structural confirmation, and stringent purity assays. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.