Description

Azido-Peg2-Pfp Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a pentafluorophenyl (Pfp) ester. This compound is a critical reagent for click chemistry and bioconjugation, enabling the efficient, site-specific coupling of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and diagnostics industries for applications such as antibody-drug conjugate (ADC) development, peptide modification, and surface functionalization.

Application

• Bioconjugation reagent for the synthesis of Antibody-Drug Conjugates (ADCs) and other protein-payload constructs.
• Functionalization of peptides, oligonucleotides, and small molecule drugs with PEG spacers via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Surface modification and labeling of nanoparticles, polymers, and solid supports for diagnostic and therapeutic platforms.
• Cross-linking agent in materials science for creating hydrogels and functional biomaterials.
• Tool compound in chemical biology for probing protein interactions and cellular pathways.
• Intermediate in the synthesis of more complex, multi-functional PEG-based linkers and scaffolds.

Basic Information

Product Name	Azido-Peg2-Pfp Ester
CAS No.	1393330-37-4
Molecular Formula	C₁₇H₁₇F₅N₄O₅
Molecular Weight	452.34 g/mol
Synonyms	2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate; Azido-PEG2-PFP ester; 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 2,3,4,5,6-pentafluorophenyl ester; PFP-PEG2-Azide; N-(Pentafluorophenyl) 11-azido-3,6,9-trioxaundecanoate; Azido-PEG2-PFP; Azido-PEG2-Pentafluorophenyl Ester; Azido-PEG2-PFP active ester
EINECS	Contact for details

Quality Control

Our Azido-Peg2-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.