Description

Azido-Peg1-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a carboxylic acid terminus. This compound is a critical building block in bioconjugation and click chemistry, enabling the efficient and selective coupling of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require reliable, high-purity linkers for creating novel drug conjugates, diagnostic probes, and functionalized nanomaterials.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry (CuAAC).
• Polymer and Surface Functionalization: Used to introduce azide groups onto polymers, nanoparticles, or solid supports for subsequent click chemistry modifications.
• Peptide and Protein Modification: Enables site-specific labeling or PEGylation of peptides and proteins to enhance stability, solubility, or pharmacokinetic properties.
• Diagnostic Reagent Synthesis: Facilitates the creation of fluorescent or radioactive probes for imaging and diagnostic assays.
• Material Science and Hydrogel Formation: Acts as a cross-linking agent or functional monomer in the synthesis of smart polymers and biocompatible hydrogels.
• Small Molecule Prodrug Synthesis: Utilized to create cleavable linkers for targeted drug delivery systems.

Basic Information

Product Name	Azido-Peg1-Acid
CAS No.	1393330-34-1
Molecular Formula	C5H9N3O3
Molecular Weight	159.15 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]acetic acid; 3,6-Dioxa-8-azaoctanoic acid, 8-azido-; Azido-PEG1-acetic acid; Azido-EG1-acid; N3-PEG1-COOH; Azido-ethyleneglycol-acetic acid; 8-Azido-3,6-dioxaoctanoic acid; PEG1-azide-acid
EINECS	Contact for details

Quality Control

Our Azido-Peg1-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the product in a freezer at -20°C or below under an inert atmosphere. The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.