Description

1-Oxa-6-Azaspiro[3.4]Octane 2,2,2-Trifluoroacetate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research. It is primarily utilized by R&D scientists and process chemists in pharmaceutical, biotechnology, and fine chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of complex molecules targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead compound discovery and optimization programs, especially for creating spirocyclic and bridged heterocycles.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in targeted protein degradation therapeutics.
• CNS Drug Discovery: Applied in the development of potential treatments for conditions like depression, anxiety, and neurodegenerative diseases.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Oxa-6-Azaspiro[3.4]Octane 2,2,2-Trifluoroacetate
CAS No.	1392804-83-9
Molecular Formula	C8H10F3NO3
Molecular Weight	225.17 g/mol
Synonyms	1-Oxa-6-azaspiro[3.4]octane, 2,2,2-trifluoroacetate; 6-Aza-1-oxaspiro[3.4]octane trifluoroacetate salt; 1-Oxa-6-azaspiro[3.4]octane TFA salt; Spiro[3.4]octane-1,6-oxazane trifluoroacetate; 2-Oxa-7-azaspiro[4.4]nonane trifluoroacetate (alternative numbering); TFA salt of 1-Oxa-6-azaspiro[3.4]octane; 1392804-83-9
EINECS	Contact for details

Quality Control

Our 1-Oxa-6-Azaspiro[3.4]Octane 2,2,2-Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.