Description

Allyl2-((3S,4R)-3-((R)-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-2-Oxo-4-(((Propylthio)Carbonothioyl)Thio)Azetidin-1-Yl)-2-Oxoacetate is a highly specialized, advanced pharmaceutical intermediate featuring a complex β-lactam (azetidinone) core. This compound is of significant value for its role as a key building block in the synthesis of novel, potent antibacterial agents, particularly within the carbapenem and penem classes. It is engineered for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-purity, structurally precise intermediates for complex API development.

Application

• Key Intermediate for Novel Antibiotics: Serves as a critical precursor in the multi-step synthesis of next-generation carbapenem and penem antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial drug candidates.
• Process Chemistry & Scale-Up: Employed in the optimization and pilot-scale production of advanced active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the preparation of structurally related β-lactam derivatives with potential therapeutic applications.
• Academic Research: Utilized in university and institutional labs for studying β-lactam chemistry, enzyme inhibition, and novel synthetic methodologies.

Basic Information

Product Name	Allyl2-((3S,4R)-3-((R)-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-2-Oxo-4-(((Propylthio)Carbonothioyl)Thio)Azetidin-1-Yl)-2-Oxoacetate
CAS No.	1392406-54-0
Molecular Formula	C20H31NO5S3Si
Molecular Weight	489.73 g/mol
Synonyms	Allyl 2-((3S,4R)-3-((R)-1-((tert-Butyldimethylsilyl)oxy)ethyl)-2-oxo-4-(((propylthio)carbonothioyl)thio)azetidin-1-yl)-2-oxoacetate; 4-(Allyloxy)-4-oxo-2-((3S,4R)-3-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-2-oxo-4-(((propylthio)carbonothioyl)thio)azetidin-1-yl)-2-oxobutanoic acid?; β-Lactam intermediate with TBS and dithioester; (3S,4R)-1-(2-Allyloxy-2-oxoacetyl)-3-[(1R)-1-[(tert-butyldimethylsilyl)oxy]ethyl]-4-(propylcarbamodithioylthio)azetidin-2-one; Advanced Penem/Carbapenem Synthon
EINECS	Contact for details

Quality Control

Our Allyl2-((3S,4R)-3-((R)-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-2-Oxo-4-(((Propylthio)Carbonothioyl)Thio)Azetidin-1-Yl)-2-Oxoacetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.