Description

n-Boc2-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity, protected pyridine boronic ester derivative, serving as a critical advanced pharmaceutical intermediate for modern drug discovery. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to synthesize novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds between the boronic ester and aryl/heteroaryl halides under palladium catalysis.
• Drug Discovery & Medicinal Chemistry: Used in library synthesis for high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and insecticides.
• Material Science: Precursor for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Chemical Biology: Tool compound for bioconjugation and probe development due to its reactive boronate and protected amine functionalities.

Basic Information

Item	Details
Product Name	n-Boc2-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1391926-49-0
Molecular Formula	C16H25BN2O4
Molecular Weight	320.20 g/mol
Synonyms	tert-Butyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine N-Boc Protected; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine, N-Boc derivative; 2-((tert-Butoxycarbonyl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Boc-2-Amino-5-(pinacolboron)pyridine; 5-(Pinacolboryl)pyridin-2-amine N-Boc
EINECS	Contact for details

Quality Control

Our n-Boc2-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.