Description

8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Decane-2,8-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic amine class of compounds. This compound is valued for its unique structural framework, which serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS).
• Agrochemical Research: Used as a building block for developing new pesticides and herbicides with novel modes of action.
• Chemical Synthesis Scaffold: Its rigid spirocyclic structure makes it a valuable scaffold in medicinal chemistry for creating libraries of compounds for high-throughput screening.
• Ligand and Catalyst Development: Employed in the research and development of specialized ligands and organocatalysts for asymmetric synthesis.
• Academic & Industrial R&D: Serves as a standard or starting material in research laboratories for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Decane-2,8-Dicarboxylate
CAS No.	1391732-45-8
Molecular Formula	C16H27NO4
Molecular Weight	297.39 g/mol
Synonyms	tert-Butyl 2-methyl 8-azaspiro[4.5]decane-2,8-dicarboxylate; 8-Azaspiro[4.5]decane-2,8-dicarboxylic acid, 2-methyl-, 1,8-di-tert-butyl ester; 8-tert-Butoxycarbonyl-2-methyl-8-azaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; 2-Methyl-8-azaspiro[4.5]decane-2,8-dicarboxylic acid di-tert-butyl ester; 8-Boc-2-methyl-8-azaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; Spirocyclic amine diester intermediate; CAS 1391732-45-8
EINECS	Contact for details

Quality Control

Our 8-tert-Butyl 2-Methyl 8-Azaspiro[4.5]Decane-2,8-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.