Description

4-Azido-n-Fmoc-D-Phenylalanine is a specialized, non-natural amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound matters for its unique azido functional group, enabling highly selective, bioorthogonal click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for researchers and manufacturers in pharmaceutical R&D, proteomics, and chemical biology who require precise site-specific labeling and modification of peptides, proteins, and other biomolecules.

Application

• Peptide Drug Discovery: Incorporation into peptide sequences for subsequent site-specific conjugation with payloads (e.g., fluorophores, toxins, polymers).
• Chemical Biology Probes: Synthesis of activity-based probes for target identification and validation in complex biological systems.
• Bioconjugation & ADC Development: A key building block for the synthesis of linker-payload systems in Antibody-Drug Conjugates (ADCs) and other biopharmaceuticals.
• Materials Science: Functionalization of surfaces and polymers via click chemistry to create bioactive materials and hydrogels.
• Proteomics Research: Metabolic labeling and enrichment strategies for studying protein expression, interactions, and post-translational modifications.
• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid building block in automated peptide synthesizers.

Basic Information

Product Name	4-Azido-n-Fmoc-D-Phenylalanine
CAS No.	1391586-30-3
Molecular Formula	C24H20N4O4
Molecular Weight	428.44 g/mol
Synonyms	Fmoc-D-Phe(4-N3)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-azido-D-phenylalanine; Fmoc-4-azido-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-azidophenyl)propanoic acid; 4-Azido-D-phenylalanine, N-Fmoc derivative; Azido-Fmoc-D-Phe-OH; Fmoc-D-4-Azido-Phe-OH; Fmoc-D-Phenylalanine(4-azido)
EINECS	Contact for details

Quality Control

Our 4-Azido-n-Fmoc-D-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and our QC protocols are designed to meet the stringent requirements of pharmaceutical development and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term storage, desiccate to protect from moisture. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥95.0%
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.